Granisetron
[Chemical Name]:endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H -indazole-3-carboxamide hydrochloride
[Description]:
5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy and radiation therapy.
[Structure]:
[Formula]:C18H24N4O.HCL
[Molecular Weight]:348.9
[CAS RN]:107007-99-8(Hcl),109889-09-0(Base)
[Specification]:EP,BP,USP
Appearance |
White to almost white powder |
| Identification |
A IR Spectrum |
| |
B Chloride |
|
Sample IR spectrum comparable with that of the standard.
Positive |
LossandDrying |
0.5% max |
Solution Clarity |
Clear and colourless |
pH |
4.6-6.6 |
Impurity E(by TLC) |
0.5% max |
Sulfate ash |
0.1% max |
Related Substances |
Impurity A: 1.0% max |
Impurity B: 0.5% max |
Impurity C: 0.2% max |
Impurity D: 0.1% max |
Any other impurity: 0.1% max |
Total Impurity: 1.0% max |
AssaybyHPLC (drying basis) |
97.0%-102.0% |
|
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